The same mighty drugs that have stretched the lives of innumerable human with HIV come with a cost - insulin resistance that tin guide to diabetes and cardiovascular ailment (CVD). Now, researchers at Washington University School of Medicine in St . Louis have resolved why that happens. Their research shows that HIV protease inhibitors (protease inhibitor) directly interfere with the access blood sugar levels are controlled in the body. This leads to insulin resistance, a condition that occurs when the body produces enough insulin merely doesn't use it properly.
This confirmation provides the latent to amplify safer antiviral drugs.
Paul Hruz Air Jordan 10 Retro, MD, PhD, acolyte professor of pediatrics (pediatric) and of cell biology and physiology at the School of Medicine Air Jordan 24 Retro, and his team base thahead of-generation protease inhibitors Air Jordan 5 Retro, including the drug ritonavir, block GLUT4, a protein namely transports glucose (glucose) from the blood into the cells where it namely needed. This heaves blood sugar levels - a hallmark of diabetes.
senior author of the study published in the Nov. 19 Journal of Biological Chemistry. >
Hruz's lab made the finding in mice that lacked the GLUT4 protein. When researchers gave these mice ritonavir, the drug had not efficacy on their glucose tolerance. However, when they gave the drug to regular mice Jordans white, their blood glucose shot up quite quickly, showing that the drugs injure glucose tolerance and promote insulin resistance.
when insulin resistance goes on for a long period, secondary changes develop, such for tall triglycerides (TG), and those are harder to reverse, comprehend the character of glucose transporters in health and disease Jordan 14 Shoes, including the epidemic of type 2 diabetes in HIV negate patients Air Jordan shoes black, says Hruz. He expects the results will assist scientists better understand how to develop current diabetes drugs and the character of glucose transport in diseases such for heart failure.
Hruz and his team are now studying by the molecular class how the HIV pills curb GLUT4.
with the transporter to aid the development of better HIV drugs, already is working with a drug developer to establish a new HIV drug that the virus does no develop resistance to and does not block GLUT4.
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